Key publications

[REVIEW ARTICLE] Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023)

Wang S*, Friedman SL*. Science Translational Medicine, 15(716), adi0759


*Corresponding author

A stellate cell autocrine signaling circuit facilitated by cell-cell contacts in non-alcoholic steatohepatitis (2023)

Wang S, Li K, Pickholz E, Dobie R, Matchett KP, Henderson NC, Carrico C, Driver I, Borch Jensen M, Chen L, Petitjean M, Bhattacharya D, Fiel MI, Liu X, Kisseleva T, Alon U, Adler M, Medzhitov R, Friedman SL. Science Translational Medicine (cover story), 15(677), eadd3949 

Highlighted in: Nature Reviews Drug Discovery 2023 Jan 18. doi:, Nature Reviews Gastroenterology & Hepatology 2023 Feb 08 doi:

Epigenetic compensation promotes liver regeneration (2019)

Wang S, Zhang C, Hasson D, Desai A, SenBanerjee S, Magnani E, Ukomadu C, Lujambio A, Bernstein E and Sadler KC. Developmental Cell, 50(1):43-56.e6. doi: 10.1016/j.devcel.2019.05.034 

Highlighted in: Nature Reviews Molecular Cell Biology 2019 Jul 4. doi: 10.1038/s41580-019-0157-8 & Developmental Cell. 2019 Jul 1;50(1):3-4. doi: 10.1016/j.devcel.2019.06.006

Other publications (chronological)

Vacca M, Kamzolas I, Harder LM, Oakley F, Trautwein C, Hatting M, Ross T, Bernardo B, Oldenburger A, Hjuler ST, Ksiazek I, Lindén D, Schuppan D, Rodriguez-Cuenca S, Tonini MM, Castañeda TR, Kannt A, Rodrigues CMP, Cockell S, Govaere O, Daly AK, Allison M, de Lichtenberg KH, Kim YO, Lindblom A, Oldham S,  Andréasson A-C, Schlerman F, Marioneaux J, Sanyal A, Afonso MB, Younes R, Amano Y, Friedman SL, Wang S, Bhattacharya D, Paradis V, Burt A, Davies S, Driessen A, Yashiro H, Pors S, Andersen MW, Feigh M, Yunis C, Bedossa P, Stewart M, Cater HL, Wells S, Anstee QM, Tiniakos D, Perfield JW, Petsalaki E, Davidsen P, Vidal-Puig A on Behalf of the LITMUS Investigators. An unbiased ranking of murine dietary models based on their proximity to human Metabolic Dysfunction–associated Steatotic Liver Disease (MASLD) (2024). Nature Metabolism (in press)

Yashaswini CN, Bhattacharya D, Amor C, Lowe S, Lujambio A, Wang S, Friedman SL (2024). Phenotypes and Ontogeny of Senescent Hepatic Stellate Cells in Human and Mouse Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), Journal of Hepatology (in press)  

Carter JK, Tsai MC, Venturini N, Hu J, Lemasters JJ, Wang S, Lee YA, Friedman SL (2024). Protocadherin 7, a novel stellate cell specific adhesion molecule, is a rheostat of sinusoidal contractility and cellular inactivation. Hepatology (in press)

Cogliati B, Yashaswini C, Wang S, Sia D, Friedman SL (2023). Friend or Foe? The Elusive Role of Hepatic Stellate cells in Liver Cancer, Nature Reviews Gastroenterology & Hepatology, doi: 10.1038/s41575-023-00821-z

Wang S*, Ruiz de Galarreta M, Sadler KC, and Lujambio A (2021). Manipulating and tracking single hepatocyte behavior during mouse liver regeneration by performing hydrodynamic tail vein injection. STAR protocols, 2(2):100440. doi: 10.1016/j.xpro.2021.100440

Carter JK, Wang S, Friedman SL (2021). Ten Thousand Points of Light–Heterogeneity Among the Stars of NASH Fibrosis. Hepatology, doi: 10.1002/hep.31807

Trivedi P, Wang S, Friedman SL (2021). The power of plasticity—metabolic regulation of hepatic stellate cells. Cell Metabolism, doi: 10.1016/j.cmet.2020.10.026

Wang S and Friedman SL (2020). Taming the savage breast from within: Transcription factor 21, a regulator of stellate cell deactivation. Hepatology, doi: 10.1002/hep.31151

Ruiz de Galarreta M, Bresnahan E, Molina-Sánchez P, Lindblad KE, Maier B, Sia D, Puigvehi M, Miguela V, Casanova-Acebes M, Dhainaut M, Villacorta-Martin C, Singhi AD, Moghe A, von Felden J, Grinspan LT, Wang S, Kamphorst AO, Monga SP, Brown BD, Villanueva A, Llovet JM, Merad M, and Lujambio A. (2019). β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma. Cancer Discovery, 9(8):1124-1141. doi: 10.1158/2159-8290.CD-19-0074.

Wang S and Friedman SL (2019). Hepatic fibrosis: a convergent response to liver injury that is reversible. Journal of Hepatology, doi: 10.1038/s41568-020-00330-0

Wang S*, Hanna D, Sugamori KS, Grant DM* (2019). Primary aromatic amines and cancer: Novel mechanistic insights using 4-aminobiphenyl as a model carcinogen. Pharmacology & Therapeutics, doi: 10.1016/j.pharmthera.2019.05.004

Wang S, Miller SR, Ober EA, Sadler KC (2017). Making it new again: insight into liver development, regeneration, and disease from zebrafish research. Current topics in developmental biology. doi: 10.1016/bs.ctdb.2016.11.012

Chernyavskaya Y, Mudbhary R, Tokarz D, Jacob V, Gopinath S, Zhang C, Sun X, Wang S, Yoder JA, Hoshida Y and Sadler KC (2017). Hypomethylation of self-DNA in zebrafish induces transposon expression and activates the interferon response via cytoplasmic viral sensors. Development, 144(16):2925-2939

Wang S, Tung A, Bott D, Sugamori KS, Grant DM (2015). The roles of CYP1A2 and CYP2E1 in the bioactivation and detoxification of 4-aminobiphenyl in adult mice. Drug Metabolism and Disposition, 43(7):916-21

Wang S, Tung A, Sugamori KS, McPherson PJ, Grant D (2015). The N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically-induced liver cancer. Toxicological Sciences, 144(2):393-405

Ogawa S, Surapisitchat J, Virtanen C, Ogawa M, Niapour M, Sugamori KS, Wang S, Tamblyn L, Guillemette C, Hoffmann E, Zhao B, Strom S, Laposa RR, Tyndale RF, Grant DM, Keller G (2013). Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes. Development, 140(15):3285-96

Wang S, Sugamori KS, Brenneman D, Hsu I, Calce A, Grant DM (2012). Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver. Environmental and Molecular Mutagenesis, 53(5):350-7 (Editor's pick for this issue)

*Corresponding author